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Health is one factor that improves the quality of life and well being of people and thus, researchers have investigated various aspects that influence health outcomes of a society. The conceptual literature points to several factors which influence health status and these can broadly be grouped according to economic, social, environmental and biological and endowment determinants. Using a panel consisting of 37 countries, this paper seeks to identify those variables that are statistically robust in determining health status for Latin America and the Caribbean. The study finds that increases in health expenditure as a ratio of GDP, per capita calorie availability and literacy rate add to a population’s health status (as measured by life expectancy), while per capita carbon dioxide emissions reduce longevity.